Adenosine A1 receptor activator T62

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

腺苷 A1 受体激活剂 T62 是腺苷 A1 受体的变构增强剂，在急性疼痛动物模型中产生镇痛作用，并降低炎症和神经损伤疼痛模型中的超敏反应。

Adenosine A1 receptor activator T62 is an allosteric enhancer of adenosine A1 receptor, and it produces antinociception in animal models of acute pain and also reduces hypersensitivity in models of inflammatory and nerve-injury pain[2][3].(In Vivo):Adenosine A1 receptor activator T62 (0.3-3 μg; intrathecal administration; male SpragueDawley rats) treatment produces a dose-dependent antihypersensitivity effect. However it has no effect on ambulation or activity level.

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Adenosine A1 receptor activator T62 (0.3-3 μg; intrathecal administration; male SpragueDawley rats) treatment produces a dose-dependent antihypersensitivity effect, with no effect on ambulation or activity level. Animal Model:Male SpragueDawley rats (250 g) after paw incision surgery Dosage:0.3 μg, 0.5 μg, 1 μg, and 3 μg Administration:Intrathecal administration Result:Produced a dose-dependent antihypersensitivity effect, with no effect on ambulation or activity level. The ED40 (95% confidence interval) was 0.77 (0.63-0.91) μg.

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Apoptosis

Adenosine Receptor

PDE4

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40312-34-3

291.79

C15H14ClNOS

>98% (HPLC)

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Nc1sc2CCCCc2c1C(=O)c1ccc(Cl)cc1

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(-20℃)

With Ice Pack

≥ 2 years